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The investigators concluded that nasal airway absorption was not increased in smokers compared to nonsmokers

importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2

The absorption spectra clearly suggest that TPE-DCV can react with GSH, Cys and Hcy through thiol-ene click reaction to form thioether (Figure S5)

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