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A cyclic nucleotide derived from GTP that acts as a second messenger, much like cyclic AMP

GLP-1R expression by immunohistochemical staining suggested that there was a marked increase in the expression in the PSCs, with activation (compare Figures 6a vs 6b)

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[1] [2] The potential cardioprotective mechanisms of certain GLP-1 receptor agonists may involve improvements in glycemic control, weight reduction, blood pressure lowering, and possibly other effects on vascular function, though the exact mechanisms continue to be studied

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