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The enzymes DNA methyltransferases catalyze the transfer of methyl groups, derived from SAM, to the CpG islands in the promoter region of a gene, preventing the interaction of this region with the transcriptional machinery and consequently blocking gene expression (Triantaphyllopoulos et al., 2016) ( Figure 1 )

Liver function tests (LFTs) measure markers like ALT, AST, and GGT to assess liver health and metabolic function 1,2 3

Raw sequence reads were aligned to the human genome (hg38) using the Tophat algorithm 80 and Cufflinks algorithm 81 was implemented to assemble transcripts and estimate their abundance

Synthetic compounds such as Verampil affect MATE pumps in Mycobacterium tuberculosis , resulting in an antibiotic-potentiating effect with Bedaquiline and Ofloxacin 78