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In a study involving in vivo models, altered hepatic uptake of metformin was observed in pseudo-germ-free rats compared to conventional diabetic rats

GLP-1 drugs interact with brain regions that regulate wakefulness

Peripheral anti-A antibody alters CNS and plasma A clearance and decreases brain A burden in a mouse model of Alzheimer's disease

Both therapies converge on the same cellular signaling pathways, and their combined effect may be greater than the sum of their parts

The importance of the AsA-GSH cycle in alleviating cold stress was further reinforced with the transcriptomic analysis on the AsA-GSH cycles genes, which shows upregulation of genes such as CaAPX1, CaGR2, CaMDHAR1 , and CaDHAR1 (Yao et al., 2021)