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Notably, Compound 86 engaged only F392 and F424 and formed a single hydrogen bond with H267, whereas 8HP and DSR-141562 displayed additional interactions with H373, Q421, D370, and Y222, with 8HP exhibiting the highest affinity due to extra aromatic contacts (Figures 26AC)

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List downloaded from Dataset DOI:10.5281/zenodo.4587355 A - Alimentary tract and metabolism A16 - Other alimentary tract and metabolism products A16A - Other alimentary tract and metabolism products A16AA - Amino acids and derivatives A16AA01 - Levocarnitine Absorption Absolute bioavailability is 15% (tablets or solution)