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Cultured gestational day 9.5 mouse embryos treated with phenytoin displayed substantially higher levels of 8-OH-2-dG DNA modifications than vehicle-treated control embryos and significant developmental damage
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Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial
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Furthermore, brain organoids and three-dimensional culture models are employed for high-throughput drug screening because they can replicate the networks involved in iron metabolism in the human brain ( 3.5 Stroke 3.5.1 Ischemic stroke Mounting studies have revealed that ischemic stroke increases iron deposition, mitochondrial dysfunction, LP, and iron overload
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