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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)
, 104 , 144-164, doi: Chatterjee, A., and Gupta, S
Each of these chronic conditions impacts millions of Americans, meaning GLP-1RAs could one day be the most common medication in the U.S
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