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postulated to be responsible for the high incidence of severe necrotic skin infections and ulcerations Severe skin infections often require hospitalization with treatment including i.v
In general cyanocobalamin isn't retained as long as hydroxocobalamin so maintenance dosing tends to be more frequent - think in the states they tend to do loading doses as daily for one or two weeks followed by weekly for a few months and then monthly
Tirzepatide (Zepbound/Mounjaro) shows similar 3-5% rates
American Association of Clinical Endocrinology Consensus Statement: Algorithm for the Evaluation and Treatment of Adults With Obesity/Adiposity-Based Chronic Disease 2025 Update
Tirzepatide Dosage for Weight Loss Key Highlights Tirzepatide, also known as Mounjaro and Zepbound, helps people control their weight with easy injections
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