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Some sources suggest shorter windows for certain compounded formulations, so check with your pharmacy for their specific guidance

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RNA-small molecule interaction detection by DMS-MaPseq The target RNA was folded by adding 1 PKN buffer (20 mM phosphate, 80 mM KCl, and 20 mM NaCl at pH 7.0), followed by heating at 95 C for 5 min and cooling on ice