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doi: 10.1016/j.kint.2025.07.023 26 ParkJJooYSNamBYKimGParkJTYooTHet al
Thus, glutathione is an essential part of the way cells balance ROS on a constant basis, as well as being available in situations where oxidative stress is generated by toxins, disease, or other pathological conditions.[ref] Glutathione peroxidase (GPX1, GPX2,3,4) antioxidant in cells Glutathione S-transferases (GSTs) are a family of enzymes that bind glutathione to toxic substances to remove them from the cell and then out of the body
Additionally, caution should be exercised when used by patients with renal or hepatic impairment
However, it did improve anxiety symptoms in the patients.[ref] A meta-analysis of clinical trials using 900 2700 mg/day showed that NAC may improve hearing loss (noise-induced).[ref] Keep in mind that these studies involved patients who were likely to have increased glutathione use
Studies on topical delivery typically show effects concentrated in the epidermis and upper dermis
