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That work involved experimental models and applied mainly to impaired liver function

For sperm, it can take three months or longer to see significant changes

As such, glutamine is recognized as a conditionally essential amino acid

Since it participates in the synthesis of GSH, this enzyme plays a key role in the cellular redox homoeostasis ( The majority of plasmatic GSH originates from the liver, and for this reason an impairment in hepatic GSH synthesis has a systemic impact on redox balance and oxidative stress ( 2.2

However, it should be noted that GSH at high concentrations (e.g., 30 mM) induces morphological changes in HFF-1 cells (Supplementary Figure S1E)