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Anil Makam, M.D., an internal medicine physician at the University of California, San Francisco, notes that GLP-1s may be a future therapeutic option for people with substance use disorders

These distinct pathways suggest that concurrent use is unlikely to result in direct pharmacological interference

Presented for research literature review only Hollingworth RM et al

The current recommendation of selecting specific SGLT2is or GLP1-RAs on the basis of proven benefits such as weight reduction and cardiovascular or renal effects may also be valid for combined therapy

Each has distinct pharmacokinetic profiles, onset times, and patient tolerance patterns