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If you experience any suspected side effects, report them to the MHRA through the Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

In December 2025, the TRIUMPH-4 trial reported that retatrutide 12 mg achieved a remarkable 28.7% mean weight loss at 68 weeks in patients with obesity and knee osteoarthritis, with substantial pain relief as well ( [71] )

the reconstituted form is not

At 48 weeks on the 12 mg dose, 100% of participants achieved at least 5% weight reduction, 93% achieved at least 10%, and 83% achieved at least 15%

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