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Contact your GP or prescribing clinician if you experience: Persistent or severe nausea and vomiting that prevents adequate food or fluid intake, particularly if lasting more than 24-48 hours, as this raises concerns about dehydration and nutritional deficiency Severe abdominal pain , especially if sharp, persistent, or located in the upper abdomen radiating to the back, which could indicate pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists mentioned in the Wegovy SmPC [8] [4] Signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst Rapid or unintended weight loss that exceeds your expected rate Blood in vomit or stools , which requires urgent assessment (call NHS 111 or 999, or attend A&E) Symptoms of gallbladder disease such as severe right upper abdominal pain, particularly after fatty meals, as rapid weight loss can increase gallstone risk (noted in the Wegovy SmPC) [4] [9] Severe constipation with abdominal distension , which could indicate bowel obstruction Dietary intolerances that significantly impact quality of life or nutritional adequacy should also be discussed with your healthcare team

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The initial weight loss in the first few weeks is often due to water loss, glycogen (stored carbohydrates), and salt

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Learn more about it here: How Does Semaglutide Work for Weight Loss