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In agreement with earlier reports, we observe features consistent with mitochondrial biogenesis, including upregulation of key regulators such as peroxisomal proliferating activating receptor coactivator-1 (PGC-1 ) and mitochondrial transcription factor A (TFAM), as well as reduced expression of key glycolytic enzymes, exemplified by downregulation of hexokinase 2 (HK2, data not shown)
Tibon NS, Ng CH, Cheong SL (2020) Current progress in antimalarial pharmacotherapy and multi-target drug discovery
Participants who combined semaglutide with calorie reduction, consistent physical activity, and adequate sleep lost significantly more than those relying on medication alone
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