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StatPearls notes that high-dose oral B has been shown effective for maintenance, but recommendations are to always use the parenteral route in severe neurological manifestations
Proactive laxative use during dose increases can prevent severe symptoms
Patients who have undergone gastric bypass or other bariatric procedures have surgically altered anatomy that reduces the absorptive surface area in the stomach and small intestine
Development for the obesity indication was discontinued in 2007 as a direct result of that Phase IIb outcome
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