constipation and tirzepatide severe : r/tirzepatidecompound tirzepatide vs semaglutide constipation vs.

Tirzepatide (the drug in Mounjaro and Zepbound) works differently from semaglutide because it mimics two hormones rather than one: GLP-1 and GIP

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For participants who had been taking liraglutide an earlier-generation GLP-1 receptor agonist the same meta-analysis found a smaller mean weight regain of 2.20 kg over the follow-up period (Berg et al., 2025)

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Whilst these findings were encouraging, the study was relatively small and designed primarily to assess safety and feasibility rather than definitive efficacy