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In addition to the high cost of the drugs, there have also been intermittent shortages of the drugs, which is also why some people have turned to compounding pharmacies In May, the FDA told "Good Morning America" that while the medications are eligible for compounding because of shortages, the compounded versions "pose a higher risk." "Compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, effectiveness, or quality," the agency said in a statement at the time

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This is a reasonable extrapolation from the mechanism, but it is not established by clinical trials

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