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The protective association held up across different types of overdose
According to FDA prescribing information, the most frequently reported adverse reactions include: Gastrointestinal symptoms: Nausea (24-30% of patients) often most pronounced after dose increases Vomiting (8-12% of patients) typically occurs when nausea is severe or unmanaged Diarrhea (18-24% of patients) can range from mild to moderate in severity Constipation (16-17% of patients) paradoxically occurs alongside diarrhea in some individuals Abdominal pain or discomfort (10-14% of patients) often described as cramping or bloating Dyspepsia (6-9% of patients) indigestion, heartburn, or upper abdominal discomfort Gastroesophageal reflux disease (5-7% of patients) Eructation (belching) (5-7% of patients) These symptoms frequently overlap and compound one another
Drug repurposing, defined as researching new indications for already approved drugs, is gaining attention as a rapid and cost-efficient strategy for developing new treatments, the researchers wrote
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The results showed that LY3298176 had a dose-dependent effect on reducing HbA1c levels, and the reduction was greater than that achieved with dulaglutide or the placebo
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