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The PD-L1 promoter contains HREs and is a specific target of HIF-1, which may be upregulated in hypoxic environments [303]
Co-cultures of organotypic brain tissue overlaid on endothelial cells have permitted microdialysis experiments and measurements of TEER (Duport et al., 2014)
There is generally less adipose tissue in this area
It can also induce growth of the cartilage and skeletal muscle 4
Many studies are pre-clinical (animal models) or small human trials making it harder to generalize to broad populations, especially those with complex sleep disorders such as sleep apnea or chronic insomnia
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