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In another study, researchers have found that under HG conditions, the expression of Sirt3 is reduced in retinal pigment epithelial (RPE) cells, the Foxo3a/PINK1/Parkin pathway is inhibited, mitophagy is weakened, and overexpression of Sirt3 can activate the Foxo3a/PINK1/Parkin signaling pathway, increase mitophagy, and inhibit cell apoptosis [157]

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