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Berberine effects on intestinal motility, gut pH, and intestinal enzyme activity could theoretically influence oral tirzepatide bioavailability, though this specific interaction has not been studied
These benefits are largely independent of their glucose-lowering effects
Among 173 RA patients with overweight or obesity who were prescribed GLP-1 agonists and actually took them, 32% showed improvement in RA disease activity after 1 year, compared with 17% of 42 patients who were also prescribed the drugs but never started them, according to Veena Ranganath, MD, MS, of the University of California Los Angeles (UCLA), and colleagues
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Subsequent investigational work explored ghrelin-receptor agonists like ipamorelin for conditions such as postoperative ileus, but ipamorelin never reached an approved marketed indication
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