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In the forest plot, several studies including Harmony Outlets (2018), LEADER (2016), REWIND (2019), and SUSTAIN-6 (2016) appear to show a low risk of respiratory diseases
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Given the stable HRs across the spectrum of frailty, these differences in number needed to treat between frail and non-frail people are primarily driven by the higher number of events among frail patients, which highlights the greater vulnerability of this population. Lower CV risk with SGLT2 inhibitors vs
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