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They stimulate fibroblasts to produce new collagen and elastin, thicken the dermis and restore elasticity
Resources Used: Bartel, Sara et al
Based on current phase 3 TRIUMPH trial timelines, a regulatory submission to the MHRA is not anticipated before 20262027 at the earliest, with a possible marketing authorisation in 20272028 and NHS availability potentially from 2028 onwards, subject to NICE appraisal
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Anecdotally, vivid dreams appear more common during dose escalation periods and tend to normalize after reaching a stable maintenance dose
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