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Randomized trials show dose escalation protocols (starting at 0.25 mg, advancing by 0.25 mg every 4 weeks) produce significantly fewer nausea reports than fixed higher doses
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doi: 10.1053/j.gastro.2012.06.031 78 WahlstrmA.SayinS
Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A, American Heart Association Council on Basic Cardiovascular Sciences
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