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1a), enabling controlled induction of mitophagy
Eight weeks of high fat diet in mice decreased insulin sensitivity and manganese-dependent SOD activity while increasing malondialdehyde, all of which was prevented by co-administration of trimetazidine (10 mg/kg/day, intragastric) [184]
In addition, cellular cysteine is also available through the transsulfuration (TSS) pathway from the sulfur-containing amino acid methionine
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