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While these strategies are primarily used for gastrointestinal side effects , they can also reduce injection site reaction severity by delivering smaller volumes per injection

Cardiovascular Health Drinking heavily can have a negative effect on the heart and blood vessels

doi: 10.1371/journal.pone.0155694 14 CunnaneS.NugentS.RoyM.Courchesne-LoyerA.CroteauE.TremblayS.et al

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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies