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This random assignment ensured that half of the participants started the study with morning injections and the other half with evening injections.The schedules were standardized to 08:0009:00 and 20:0021:00, respectively, according to the patient's age

Siegel EG, Gallwitz B, Scharf G, Mentlein R, Morys-Wortmann C, Folsch UR, Schrezenmeir J, Drescher K, Schmidt WE (1999) Biological activity of GLP-1-analogues with N-terminal modifications

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