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Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12

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The overexpression of MFN2 enhances mitochondrial fusion to prevent mitochondrial fragmentation (96) and alleviates the decrease in mitochondrial membrane potential and excessive ROS induced by angiotensin II (97)