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2.3 GLP-1: from glucose-lowering strategy to a multi-system metabolic protection platform As a core incretin secreted by enteroendocrine L-cells, not only regulates insulin and glucagon secretion in a glucose-dependent manner but also serves as a central controller of energy homeostasis
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Clinical evidence supporting this is mixed: IV glutathione shows consistent benefit in controlled trials, while oral forms show almost none unless formulated for enhanced absorption
Electrolytes (sodium, potassium, magnesium) may be important if a patient experiences significant GI side effects like severe vomiting or diarrhea
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