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The reported ratio became the seven orders of magnitude more potent than BDNF claim

Nature 597 , 420425 (2021)

The ENGOT-ov65/KEYNOTE-B96 Phase III study demonstrated that checkpoint inhibitor pembrolizumab combined with weekly paclitaxel with or without bevacizumab, an anti-angiogenic monoclonal antibody, achieved a statistically significant overall survival benefit over weekly chemotherapy with/without bevacizumab

[5] Researchers should be cautious when interpreting effects that appear only at high concentrations, especially if those effects are accompanied by reduced cell viability, stress-response signatures, broad transcriptional disruption, or vehicle-sensitive assay behavior

Jones, P