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Expression of the GPX5 gene is restricted to the epididymis in the male gonads and the encoded proteins function to protect the membranes of spermatozoa during their maturation
Additionally, microbiota-driven inhibition of the ornithine pathway represents another potential route for ferroptosis induction, which may contribute to the pathogenesis of PCOS
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That gives it a clean theoretical connection to testosterone biology: GnRH can increase pituitary gonadotropin signaling, and LH is the key downstream signal for Leydig-cell testosterone synthesis
Therefore, 23 clinical studies published from 2020 to 2025 are presented from various countries that examined oral collagen supplementation in women who were aged 30 to over 65 years (Table 1)
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