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It would also be pertinent to add laboratory assays that allow putting the results in the larger context of cellular senescence, which seems to be disturbed in several disorders where fatigue has been associated with mitochondrial dysfunction

Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, et al

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Figure 1 Given that the E4 allele is associated with both an increased reliance on alternative fuels, such as FAs, and more severe cerebrovascular dysfunction with age (Yassine and Finch, 2020