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With respect to VPA, this agent depletes carnitine stores, especially during long-term or high-dose therapy, through various synergistic mechanisms [22, 3841]
[Glutathione reductase and glutathione S-aryltransferase in the rat liver depending [PMID: 3705515] Laboratory literature summary: [Glutathione reductase and glutathione S-aryltransferase in the rat liver depending upon the glutathione level]
3h), demonstrating that it is, at least to some degree, under the control of the mTOR pathway
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