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The initial coordinates for the simulation input files and the coordinate files for the final output of PDL1_WT, PV2_WT, PV2_C23pAcF, PV2_C96pAcF, and PV3_WT are provided as supplementary files

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A number of studies have shown that GLP-/GIPR dual agonists can achieve better blood glucose control, insulin sensitivity, lipid metabolism and weight loss compared with GLP-1 alone [136,137]