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Lentigines assume a particular importance when their presence is associated with a variety of inherited systemic conditions, including PeutzJeghers, LEOPARD (multiple lentigines) and Carneys syndromes, centrofacial lentiginosis, and LaugierHunziker syndrome (idiopathic lenticular mucocutaneous pigmentation)

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Melatonin significantly increased MT1R and MT2R mRNA expression in treated animals to 70% and 80% of the FM group, as shown in Fig

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