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Vitamin B12 appears in the milk of nursing mothers in concentrations that approximate the mother's vitamin B12 blood level

Pregnancy and breastfeeding are also contraindications due to insufficient safety data

Controlled negative result: topical GHK-Cu gel on irradiated rat dorsal flaps showed no difference versus control in flap ischemia, vessel number/area or VEGF expression counter-evidence that the copper-tripeptide class is not uniformly effective even topically

Neither approach has proven superior

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