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Lynch, T
Invest Ophthalmol Vis Sci 2005
Importantly, there are numerous studies showing, through the regulation of the aforementioned transcription factors and more, that 4-HNE causes cell cycle arrest and inhibits the proliferation of malignant cells through the p53 and p21 dependent pathways (for review see ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)
However, its essential to follow medical guidance, as excessive B12 supplementation may not provide additional benefits
In recent years, interest in the therapeutic potential of natural compounds and plant extracts with antioxidant properties has grown [17]
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