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Research suggests it participates in detoxification, peroxide reduction, and redox signaling by serving as a cofactor for glutathione-dependent enzymes
DOI: 10.3389/fnut.2026.1870484.
Some report this is because they are awake frequently through the night, they are dealing with the symptoms of depression, they are in pain, or it is challenging to complete simple daily tasks
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Dose reduction or slower titration is often the most effective clinical strategy when gastrointestinal side effects are persistent
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