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The ratiometric readout of RT only responds to GSH (10 mM), but not to glycine (10 mM), cysteine (100 M) or a series of ROS/RNS (100 M)
The doses required to match Accutanes effects would be very high and could lead to the same side effects and serious toxicity without delivering the same therapeutic benefits
20 showed that FSP1 catalyzes the regeneration of COQ10 by NAD(P)H, and the FSP1-COQ10-NAD(P)H pathway is an independent parallel system that cooperates with GPX4 and glutathione to suppress phospholipid peroxidation and ferroptosis
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