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5,12,13 These efforts have yielded six GLP-1 RAsstarting with the development of exendin-4 (Figure 1B)-based exenatide (Figure 1C), followed by liraglutide (Figure 1D), albiglutide, dulaglutide (Figure 1E), lixisenatide, and semaglutide (Figure 1F)that have been approved by the United States Food and Drug Administration (US FDA) to treat type 2 diabetes

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering

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Standards of care and common application practices for GLP-1 peptides

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