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Association between glucagon-like peptide-1 receptor agonists and risk of suicidality: a comprehensive analysis of the global pharmacovigilance database
Here's what's happening behind the scenes and what agents need to know to help clients navigate this new underwriting landscape
Sudden Blindness (NAION) Condition: NAION (eye stroke) Risk Increase: 1.32x to 4.28x higher than other drugs Onset: Sudden, painless, irreversible MDL Status: New separate MDL 3163 created Description: Stroke of the optic nerve causing permanent partial or total blindness in one eye What It Is: Nonarteritic anterior ischemic optic neuropathy (NAION) occurs when blood flow to the optic nerve is disrupted or cut off
Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses
Keywords GLP-1 Agonists SGLT-2 Inhibitors Diabetes Mellitus Chronic Kidney Disease Liver Transplantation Introduction Despite the life-saving intervention of liver transplantation for patients with ESLD (end-stage liver disease), the success of transplantation is compromised often by post-transplant complications, particularly diabetes mellitus and chronic kidney disease (CKD)
