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Three test systems, one integrated platform: Multi-species coverage: human, rat, mouse, dog, monkey Three complementary systems: microsomes, S9, hepatocytes Full LC-MS/MS method development with ICH M10 framework Seamless expansion to MetID, soft-spot analysis, and PK bioanalysis Overview Why MS-Centric Test Systems Workflow Comparison Sample Demo Case Study FAQ What Is Metabolic Stability and Why Does It Matter in Drug Discovery
It prevented proteoglycan degradation 14,15 , an effect that is likely secondary to the upregulation of aggrecan gene expression and downregulation of aggrecanase 16,17,18
doi: 10.1186/s12885-017-3055-5 150 VelmuruganBBhuvaneswariVNaginiS
It is made up of three amino acids: cysteine, glutamate, and glycine
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