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The researchers found that IGF-1 levels were lower in diabetic women with vertebral fractures, suggesting IGF-1 as a marker for the severity of vertebral fractures [10]

Pickart isolated the responsible factor and identified it as a small peptide with the sequence glycyl-L-histidyl-L-lysine

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Thymosin Alpha-1 Thymosin Alpha-1 is a peptide originally isolated from thymic tissue that modulates immune function

We also considered potential biological mechanisms underlying these effects, integrating insights from molecular and physiological studies