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Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)
Looking ahead, by optimizing delivery systems, exploring combination therapies (such as SIRT1 with GLP-1 agonists), incorporating SIRT1 gene polymorphisms for personalized treatment, and validating long-term safety, SIRT1 has the potential to evolve from a "promising target" to a "transformative therapy." SIRT1 deacetylates forkhead box class O3 (FOXO3), thereby initiating autophagy
doi: 10.1097/WOX.0B013E3182439613 11 JopkiewiczS
In this episode, your host McCall McPherson, a Physician Assistant and Thyroid Expert, shares her personal and professional journey with thyroid conditions, including hypothyroidism
Presented for research literature review only Duplancic B et al
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