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Many patients who stay on the program seem happy with their overall experience

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GLP-1 medications (semaglutide, tirzepatide) directly suppress appetite by slowing gastric emptying and signaling satiety centres in the hypothalamus the STEP-1 trial demonstrated 14.9% mean body weight reduction at 68 weeks on semaglutide 2.4mg weekly

For individuals using GLP-1 receptor agonists, appetite changes and smaller meal volumes can make nutrition consistency harder to sustain over time

Common gastrointestinal adverse events experienced by some users include abdominal pain and stomach pain, in addition to nausea, diarrhea, heartburn, and indigestion