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Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low (Lin et al., 2023)
However, in HTN and DM, chronic hyperglycemia, angiotensin II activation, and mitochondrial dysfunction exacerbate ROS production (Vejendla et al., 2024)
Role of Endogenous Opiates
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