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Conversely, if GLP-1-related blunting is selective to reward-related content, these compounds may normalize aberrant hyperreactivity in individuals with obesity or substance use disorders without reducing negative affective processing

Chromatographic separation was achieved with a Wakosil II HG column (25 4.6 cm, 5 m), using an acetonitrile/methanol (60:40, v/v) mobile phase at a flow rate of 1 ml/min

Thus, incubating human and rodent islets under high glucose conditions results in increased expression of PC1/3 and increased secretion of GLP-1 (101, 108110), while exposure of -cells to the proinflammatory cytokine, interleukin-6, also increased GLP-1 secretion (112)