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In their meta-analysis combining the results of twelve randomized controlled trials, Veronese and colleagues reported a significant decrease in depression severity after acetylcarnitine supplementation as monotherapy compared with placebo intake or no intervention [143]
Inhibition of IDH1 also sensitized CCNE1-driven tumours to olaparib in vivo (Fig
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The molecule is small, cheap to synthesise, and would be difficult to defend commercially
