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Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

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At the same time, endothelial cell senescence also affects the delivery of nutrients and oxygen, leading to metabolic abnormalities and further accelerating organismal aging (Boutouyrie et al., 2021

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This makes it one of the most broadly beneficial peptides studied in regenerative medicine